Professor Matthew Hoare

Dr. Matt Hoare is Assistant Professor of Hepatology at the University of Cambridge, group leader at the Early Cancer Institute and hepatologist at Addenbrooke’s Hospital in Cambridge. He leads the East of England service for hepatocellular carcinoma (HCC) and contributes to numerous observational and interventional clinical trials in HCC.

His research interests centre around the diseased liver microenvironment and why this drives carcinogenesis. Recent work with collaborators at the Wellcome Sanger Institute has defined the genomic consequences of chronic liver disease, allowing us to understand the burden of DNA damage and the clonal dynamics of cirrhotic nodules in CLD^1–3. This work has developed an understanding of the deranged liver microenvironment that exists in CLD. These findings have the potential to be disruptive to our understanding of the pathogenesis of CLD, translate into novel biomarkers of prognosis in CLD and potentially actionable therapeutic targets.

1. Brunner, S. F. et al. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature574, 538–542 (2019).
2. Ng, S. W. K. et al. Convergent somatic mutations in metabolism genes in chronic liver disease. Nature598, 473–478 (2021).
3. Wang, Z. et al. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Cell186, 1968-1984.e20 (2023).